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Although experimental and clinical evidence suggest that endogenous sex hormones influence bone sarcoma genesis, the hypothesis has not been adequately tested in an appropriate animal model. We conducted a historical cohort study of Rottweiler dogs because they frequently undergo elective gonadectomy and spontaneously develop appendicular bone sarcomas, which mimic the biological behavior of the osteosarcomas that affect children and adolescents. Continue reading Bone Cancer & Neutering
Effects of Gonadectomy on Health, Behavior and Performance of Pets
Are there reasons to recommend castrating or spaying pets other than to feel good about not contributing to the pet overpopulation problem and avoiding the hassle of having a litter in your home? Like any other medical procedure, gonadectomy decreases the risks of some conditions while increasing those of others. Continue reading Effects of spay or neuter on behavior & performance
A Healthier Respect for Ovaries
David J. Waters, DVM, PhD, Diplomate ACVS
Director, Center for Exceptional Longevity Studies
Gerald P. Murphy Cancer Foundation
A recent study by my research group appearing next month in Aging Cell reveals shortened longevity as a possible complication associated with ovary removal in dogs (1). This work represents the first investigation testing the strength of association between lifetime duration of ovary exposure and exceptional longevity in mammals. To accomplish this, we constructed lifetime medical histories for two cohorts of Rottweiler dogs living in 29 states and Canada: Exceptional Longevity Cohort = a group of exceptionally long-lived dogs that lived at least 13 years; and Usual Longevity Cohort = a comparison group of dogs that lived 8.0 to 10.8 years (average age at death for Rottweilers is 9.4 years). A female survival advantage in humans is well-documented; women are 4 times more likely than men to live to 100. We found that, like women, female Rottweilers were more likely than males to achieve exceptional longevity (Odds Ratio, 95% confidence interval = 2.0, 1.2 – 3.3; p = .006). However, removal of ovaries during the first 4 years of life erased the female survival advantage. In females, this strong positive association between ovaries and longevity persisted in multivariate analysis that considered other factors, such as height, adult body weight, and mother with exceptional longevity.
In summary, we found female Rottweilers who kept their ovaries for at least 6 years were 4.6 times more likely to reach exceptional longevity (i.e. live >30 % longer than average) than females with the shortest ovary exposure. Our results support the notion that how long females keep their ovaries determines how long they live. Continue reading Possible Effects of Ovary Removal
OBJECTIVE: To determine whether 9 problem behaviors in adult male dogs were affected by castration and to examine the influence of age and duration of problem behavior on behavioral effects of castration.
Continue reading Behavior neutering 2
OBJECTIVE: To determine whether gonadectomy predisposes dogs to development of age-related behavioral changes linked to cognitive impairment. Continue reading Behavior neutering
A five-year cohort study was conducted on bitches chosen by a sample of 233 randomly selected practising veterinary surgeons in the UK, to estimate the incidence of acquired urinary incontinence (AUI) in neutered and entire animals, and to investigate possible risk factors associated with neutering practices.Â Continue reading Incontinence and neutering 2
Prepubertal gonadectomy, often referred to as early-age neutering, has increased in popularity in the United States. The procedure is often used at animal care and control facilities, where puppies and kittens are neutered as early as 7 weeks of age or before adoption. Continue reading Neutering 7 wks vs 7 months