Efficacy of dog-appeasing pheromone (DAP)

Can Vet J. 2010 April; 51(4): 380–384.
PMCID: PMC2839826
Efficacy of dog-appeasing pheromone (DAP) for ameliorating separation-related behavioral signs in hospitalized dogs
Young-Mee Kim, Jong-Kyung Lee, A.M. Abd el-aty, Sung-Hee Hwang, Jae-Hoon Lee, and Sang-Mok Lee


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The study assessed the effect of dog-appeasing pheromone (DAP) on 10 typical separation-related behavioral signs in hospitalized dogs. A DAP treated group (n = 24) was compared with a placebo control group (n = 19). There was overall amelioration of the signs without ‘vigilance’ and ‘anorexia’ in the DAP-treated dogs; marked decreases were noted in elimination (P = 0.038), excessive licking (P = 0.005), and pacing (P = 0.017). The results suggest that the use of DAP could decrease separation-induced anxiety, distress, and fear in inpatients, and possibly facilitate recovery in hospitalized dogs.